13 Apr NAD+ & Psychedelic Ketamine Therapy: The “Peanut Butter & Jelly” Combo for Mental Wellness

At MY Self Wellness in Naples, Florida, we don’t believe in cookie-cutter healing. Every patient’s journey is unique — but some combinations just work. One of the most powerful pairings we’ve discovered in helping our patients heal from depression, anxiety, trauma, and burnout is NAD+ IV Therapy paired with Psychedelic Ketamine Therapy.

In fact, we like to call them the “Peanut Butter & Jelly” of mental wellness — because when combined, they nourish and support your brain and body in all the right ways.

Let’s break down how and why they work so well together.

Ketamine + NAD+: A Dynamic Duo for the Brain

Both Ketamine and NAD+ work with your brain chemistry — but they do so in different and complementary ways.

• Ketamine stimulates dopamine — your brain’s motivation and reward chemical. This helps you feel more connected, present, and emotionally open. It also helps many patients finally break free from cycles of trauma and deep depressive states.

• NAD+ (Nicotinamide Adenine Dinucleotide) helps support serotonin — the brain’s feel-good and mood-balancing chemical. It also powers up your mitochondria (your cells’ energy engines), so your brain and body can restore themselves from the inside out.

Together, these therapies offer both immediate emotional breakthroughs and long-lasting physical and emotional recovery.

The Science — Simplified

Think of your nervous system like a city with traffic jams and blackouts. Years of stress, trauma, and poor sleep can damage your brain’s highways and energy grid.

• Ketamine works like a road crew, reopening the blocked roads. It encourages neuroplasticity, the brain’s ability to grow new connections. This is why many people feel a sense of clarity, calm, and emotional healing after their sessions.

• NAD+ acts like a surge of power to the city’s grid. It recharges your brain’s cells at the mitochondrial level — the energy source of every cell. With more power, your brain starts working better, helping regulate mood, cognition, sleep, and stress response.

Individually, these therapies are transformative. But combined? They can feel life-changing.

Benefits of Combining NAD+ with Ketamine Therapy

✔️ Enhanced Mental Clarity – Many patients report that NAD+ helps them process their ketamine journeys more clearly and stay grounded post-session.

✔️ Faster Emotional Recovery – NAD+ supports serotonin production, balancing out the emotional release triggered by ketamine.

✔️ Reduced Inflammation – Both therapies help reduce systemic and neurological inflammation, which is often linked to depression, anxiety, and fatigue.

✔️ Support for Neurotransmitter Balance – While ketamine stimulates dopamine, NAD+ helps restore serotonin and overall neurotransmitter balance, promoting a more stable, long-lasting mood shift.

✔️ Improved Energy & Resilience – NAD+ helps the body bounce back — especially after emotionally intense sessions. It nourishes your nervous system and helps support more peaceful integration.

How We Use This Combo at MY Self Wellness

At MY Self Wellness, we tailor every treatment plan to the individual. Some patients choose to receive NAD+ beforeketamine therapy to prepare their nervous system and optimize neurochemical function. Others opt to receive NAD+ infusions after their psychedelic sessions to help ground the body, stabilize emotions, and extend the healing benefits.

We work with you to figure out what’s best for your biology, your schedule, and your wellness goals.

What to Expect

• Ketamine Sessions are typically administered intramuscularly in our serene Naples clinic, with full emotional and medical support from our trained team.

• NAD+ Infusions last between 90 minutes and 2 hours and can be tailored for fast or slow delivery, depending on tolerance and desired outcomes.

• ‍♀️ You’ll relax in a calming, supportive space throughout — and many patients leave feeling restored, uplifted, and more connected to themselves.

Who Is This Combo For?

This dual treatment may be especially beneficial if you’re:

• Living with treatment-resistant depression or anxiety

• Navigating PTSD or emotional trauma

• Feeling emotionally stuck or disconnected from joy

• Seeking cellular-level healing for brain fog or burnout

• Interested in long-term mental clarity and resilience

Let’s Create Your Custom Healing Plan

You don’t have to figure it all out on your own — and you’re not broken.

At MY Self Wellness, Dr. Weiss and our compassionate care team work with you to create a custom treatment plan that aligns with your unique biology, goals, and healing timeline.

We’re proud to serve Naples, Bonita Springs, Fort Myers, Marco Island, and the surrounding Southwest Florida communities with advanced psychedelic therapy and wellness services that truly transform lives.

Ready to Experience the Power of NAD+ and Ketamine Together?

Contact us today to schedule your consultation and learn how this powerful therapeutic pairing can help you reclaim your energy, clarity, and joy.