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Ketamine Therapy and Epigenetic Aging: What a New Pre-Print Study Reveals

At MY Self Wellness, we’ve always believed that ketamine therapy is more than just medicine—it’s a catalyst for healing and transformation. A recent pre-print study shared by Bryan Johnson on X offers fascinating new insights into how ketamine treatments may impact not just mental health, but also biological markers of aging.

The study, titled “Ketamine treatment effects on DNA methylation and Epigenetic Biomarkers of aging,” reported that six ketamine treatments over two to three weeks led to measurable improvements across multiple areas:

  • Depression scores: reduced by 50%

  • Overall epigenetic age: reversed by 1–2 years

  • System-age: improved by 0.5 to 3 years

  • Metabolic age: reversed by 2.9 years

  • Musculoskeletal age: reversed by 2.8 years

  • Brain age: reversed by 1.5 years

  • Inflammation age: reversed by 1.9 years

While these results are promising, it’s important to highlight that this article is still a pre-print, meaning it has not yet been peer-reviewed. In other words, these findings should not be used to guide clinical practice until further validation takes place.

Why This Matters for Healing and Growth

For years, ketamine has been recognized as one of the most effective breakthrough treatments for depression, PTSD, and anxiety. What’s exciting about this new data is that it suggests ketamine may also have measurable impacts on epigenetic aging—the biological processes that determine how our bodies function over time.

At MY Self Wellness, we know that healing is not just about symptom relief—it’s about helping you reconnect with your body, mind, and soul so you can create lasting change. Ketamine is not a “silver bullet,” but rather a powerful tool when combined with intentional integration work.

The Role of Integration Specialists

This is where our Integration Specialists come in. Unlike many clinics that simply provide the medicine and send patients on their way, we offer in-house integration support. Integration is the process of taking the insights, emotions, and breakthroughs experienced during ketamine therapy and grounding them into your daily life.

Our Integration Specialists help clients:

  • Process and make meaning of their ketamine experiences.

  • Build new daily habits that reinforce healing.

  • Develop practical tools for managing stress, relationships, and lifestyle shifts.

  • Maximize the long-term benefits of each infusion by creating a sustainable path forward.

Without integration, even the most profound psychedelic experiences risk fading into memory without lasting transformation. With integration, however, patients gain the clarity, resilience, and tools needed to truly change their lives.

Looking Ahead

The science of ketamine therapy is still evolving, and studies like this one remind us that we’re just beginning to understand its full potential. At MY Self Wellness, we remain committed to pairing cutting-edge treatment with compassionate, holistic care—ensuring every client has the support they need before, during, and after their treatments.

If you’d like to learn more about ketamine therapy and our Integration Specialists, we invite you to connect with us for a free consultation. Together, we can help you take the next step on your healing journey.

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Ketamine Therapy and our IV infusions are offered to Naples, Fort Myers, Bonita Springs, Marco Island and more.

Offering Psychedelic Ketamine Therapy to Naples, Bonita Springs, Fort Myers, Marco Island, Cape Coral and the surrounding South West Florida Area